The aim of this study is to test the moderating effect of self-esteem and negative affect on workplace bullying processes. The sample consisted of 354 Latin-American immigrants. Results of the hierarchical multiple regression analysis show that besides direct effects, self-esteem moderates the relationship between (1) work equity and bullying, as well as between (2) bullying and psychological strain and vital satisfaction. These findings are in line with behavioral plasticity theory. Negative affect showed significant main effects. However, the moderating hypothesis of negative affect is not supported. Overall, the present results suggest that an integrative model of workplace bullying should include not only contextual factors, but also personality variables.