Depression is a disorder in which the most basic human drives and desires are altered, in many cases to such a degree that life itself is threatened. The individual is always sad, hunger is extinguished or excessive, sleep is severely disrupted, sexual appetite disappear, the desire to live can be replaced by the urge to die, and so on. Although many of the secrets of depressive disorder have yielded scientific inquiries, and there is little controversy about them, some of the most basic issues in depression remain unexplained. One of them is which are the more effective treatments for depression: biological or psychological ones? The answer to this question is complex, but with the enormous amount of research conducted since the 1960’s the field is moving closer to an integrated understanding of treatment. In this review, we conclude that both kinds of treatments are effective either alone or in combination, although both interventions have limitations.