In this ex post facto study we analyzed the possible differences in the Health Related Quality of Life (HRQOL) depending on the type of transplanted organ during the first year following transplantation. The sample included 107 transplant patients: 44 of kidney, 25 of heart and 38 of liver. The transplant patients were assessed at four different phases: at the time of inclusion in the transplant waiting list, and at three, six, and twelve months from receiving the graft. All of them filled a structured interview report and SF-36 and Euroqol-5D (EQ-5D) Health Questionnaires. There are differences in HRQOL results between patients of different transplant type (kidney, heart and liver) during the transplantation process. These differences are greater in the pre-transplant phase.