The purpose of this paper is to review theory, research, and applications of Problem-Solving Therapy for depression (PST), a form of cognitive-behavioral therapy that is based on Social Learning Theory. PST is capable of broad application, and is a relatively systematic and brief form of therapy. This paper will present a synthesis of theoretical arguments for problem-solving therapy as an intervention for depression, describe two versions of PST for depression and report research supporting its utility in the treatment of depression.