The aim of this paper is to deepen the physical and psychological factors that influence the quality of life (QoL) of patients with fibromyalgia (FM). 63 women with FM and 58 healthy women were evaluated on several measures related to QoL and to physical and psychological symptoms. A significantly lower QoL was found in FM patients vs. the control group; the correlation analyses indicated, on the one hand, a significant inverse relationship between QoL and perceived intensity and interference of pain and fatigue, FM impact and psychopathological symptoms (depression, paranoid ideation, obsessive-compulsive) and somatization, measured by BSI, Brief Symptom Inventory); on the other hand, both physical function and physical role, vitality and mental health correlated positively and significantly with QoL. The regression analysis revealed that two physical variables (pain interference and physical role) and two psychological variables (obsessive-compulsive and paranoid ideation symptoms) presented the strongest relationship with QoL. These results indicate the need to address this syndrome from a multidisciplinary perspective.